Sppl3 | signal peptide peptidase 3
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Craniofacial Cardiovascular system
11 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| microphthalmia | 1 supporting dataset | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal body wall morphology | 1 supporting dataset | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 2 supporting datasets | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Sppl3em1(IMPC)Bay | heterozygote | Early adult | 9.71x10-6 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Sppl3em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| prolonged RR interval | 1 supporting dataset | Sppl3em1(IMPC)Bay | heterozygote | Early adult | 3.99x10-5 |
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External links
No external links available for Sppl3.
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| Sppl3em1(IMPC)Bay | Exon Deletion | | mouse |
| Sppl3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Sppl3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |