Sppl3 | signal peptide peptidase 3
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Craniofacial Cardiovascular system
11 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| microphthalmia | 1 supporting dataset | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal body wall morphology | 1 supporting dataset | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 2 supporting datasets | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Sppl3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Sppl3em1(IMPC)Bay | heterozygote | Early adult | 9.71x10-6 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Sppl3em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| prolonged RR interval | 1 supporting dataset | Sppl3em1(IMPC)Bay | heterozygote | Early adult | 3.99x10-5 |
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Human diseases caused by Sppl3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sppl3.
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| Sppl3em1(IMPC)Bay | Exon Deletion | | mouse |
| Sppl3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Sppl3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |