Capn12 | calpain 12

GeneMGI:1891369

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal lens morphology	3 supporting datasets	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.17x10^-6
increased circulating glucose level	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.94x10^-11
increased circulating amylase level	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.98x10^-14
cataract	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.27x10^-6
increased circulating lipase level	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.71x10^-10
decreased exploration in new environment	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.86x10^-5
abnormal retina morphology	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.77x10^-5
abnormal vitreous body morphology	1 supporting dataset	Capn12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.83x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Capn12.

Associated images

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Histopathology

There is no histopathology data found for Capn12.

IMPC related publications

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External links

No external links available for Capn12.

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*Capn12^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Capn12^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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