Prg4 | proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)

GeneMGI:1891344Synonyms: SZP, MSF, +2 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Growth/size/body region Behavior/neurological Skeleton

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	5 supporting datasets	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.2x10^-7
decreased grip strength	4 supporting datasets	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.6x10^-23
abnormal joint morphology	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.03x10^-10
abnormal skin morphology	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.12x10^-5
decreased body weight	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.11x10^-7
decreased exploration in new environment	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.23x10^-5
increased circulating potassium level	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.88x10^-5
increased anxiety-related response	1 supporting dataset	Prg4^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.18x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prg4.

Associated images

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Histopathology

There is no histopathology data found for Prg4.

IMPC related publications

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External links

No external links available for Prg4.

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*Prg4^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Prg4^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Prg4^{tm1.1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	es cell

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