Gmds | GDP-mannose 4, 6-dehydratase

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:47Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased memory-marker NK cell number	1 supporting dataset	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased CD8-positive, naive alpha-beta T cell number	3 supporting datasets	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased NK T cell number	3 supporting datasets	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased NK cell number	3 supporting datasets	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased CD4-negative NK T cell number	2 supporting datasets	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.34x10^-6
decreased mature NK cell number	2 supporting datasets	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal cranium morphology	1 supporting dataset	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.58x10^-7
decreased KLRG1-positive NK cell number	7 supporting datasets	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased erythrocyte cell number	1 supporting dataset	Gmds^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.71x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gmds.

Associated images

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Histopathology

There is no histopathology data found for Gmds.

IMPC related publications

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External links

No external links available for Gmds.

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*Gmds^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gmds^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Gmds^{tm302436(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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