Trim39 | tripartite motif-containing 39
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological
12 No significant impact
5 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased fasting circulating glucose level | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.34x10-6 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Late adult | 2.66x10-6 | ||
| absent vibrissae | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Middle aged adult | 8.44x10-7 | ||
| abnormal retina morphology | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Late adult | 3.55x10-6 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Middle aged adult | 3.78x10-9 | ||
| abnormal gait | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Middle aged adult | 1.32x10-6 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.04x10-5 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.28x10-6 | ||
| decreased locomotor activity | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Late adult | 9.53x10-6 | ||
| increased lymphocyte cell number | 1 supporting dataset | Trim39tm1b(EUCOMM)Hmgu | homozygote | Late adult | 4.97x10-6 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Trim39 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trim39.
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| Trim39tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Trim39tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Trim39tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |