Vps4a | vacuolar protein sorting 4A

GeneMGI:1890520Synonyms: 4930589C15Rik

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Immune system Integument Embryo Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Craniofacial

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:49Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



protruding tongue	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
increased spleen weight	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.94x10^-10
abnormal embryo size	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Vps4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
abnormal lens morphology	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.43x10^-5
enlarged spleen	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	heterozygote	E18.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Vps4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.86x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vps4a.

Associated images

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Histopathology

There is no histopathology data found for Vps4a.

IMPC related publications

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External links

No external links available for Vps4a.

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*Vps4a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Vps4a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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