Laptm4b | lysosomal-associated protein transmembrane 4B

GeneMGI:1890494Synonyms: C330023P13Rik

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Craniofacial

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

51Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal hindbrain morphology	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E15.5	N/A ^*
decreased prepulse inhibition	2 supporting datasets	Laptm4b^{tm1e.1(KOMP)Wtsi}	heterozygote	Early adult	1.51x10^-9
abnormal neural tube closure	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal midbrain morphology	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased startle reflex	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	heterozygote	Early adult	2.69x10^-6
abnormal embryo size	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
edema	1 supporting dataset	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Laptm4b^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Laptm4b.

Associated images

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Histopathology

There is no histopathology data found for Laptm4b.

IMPC related publications

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External links

No external links available for Laptm4b.

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*Laptm4b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Laptm4b^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Laptm4b^{tm1e.1(KOMP)Wtsi}*	Promoter excision from Targeted, non-conditional allele	‌	mouse

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