Cdh23 | cadherin related 23 (otocadherin)
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging
12 No significant impact
4 Not tested
Data collections
Gene metrics:17Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 3.37x10-5 | ||
| abnormal gait | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.03x10-14 | ||
| decreased circulating glucose level | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 7.18x10-5 | ||
| absent pinna reflex | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.05x10-18 | ||
| increased circulating sodium level | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 4.43x10-6 | ||
| impaired righting response | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 2.69x10-14 | ||
| trunk curl | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 7.25x10-20 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 2.79x10-15 | ||
| increased circulating chloride level | 1 supporting dataset | Cdh23tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.08x10-10 |
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Human diseases caused by Cdh23 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cdh23.
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| Cdh23em1H | Point Mutation | | mouse |
| Cdh23em2H | Point Mutation | | mouse |
| Cdh23em3(IMPC)H | Point Mutation | | mouse |
| Cdh23tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cdh23tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cdh23tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cdh23tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Cdh23tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cdh23tm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |