Larp1 | La ribonucleoprotein 1, translational regulator

GeneMGI:1890165Synonyms: 3110040D16Rik, Larp, +1 more

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system Craniofacial Mortality/aging Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged heart	1 supporting dataset	Larp1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged spleen	2 supporting datasets	Larp1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Larp1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
increased mean platelet volume	1 supporting dataset	Larp1^em1(IMPC)Mbp	heterozygote	Early adult	8.9x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Larp1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Larp1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Larp1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal head shape	1 supporting dataset	Larp1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Larp1^em1(IMPC)Mbp	heterozygote	Late adult	5.55x10^-9
abnormal heart morphology	1 supporting dataset	Larp1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Larp1.

Associated images

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Histopathology

There is no histopathology data found for Larp1.

IMPC related publications

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External links

No external links available for Larp1.

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*Larp1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Larp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Larp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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