Larp1 | La ribonucleoprotein 1, translational regulator
Physiological systems
22 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system Craniofacial Mortality/aging Renal/urinary system
9 No significant impact
2 Not tested
Data collections
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Larp1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Larp1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Larp1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Larp1em1(IMPC)Mbp | heterozygote | Early adult | 8.9x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Larp1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Larp1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Larp1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal head shape | 1 supporting dataset | Larp1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Larp1em1(IMPC)Mbp | heterozygote | Late adult | 5.55x10-9 | ||
| abnormal heart morphology | 1 supporting dataset | Larp1em1(IMPC)Mbp | heterozygote | Late adult | N/A * |
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This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Larp1.
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| Larp1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Larp1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Larp1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |