Adar | adenosine deaminase, RNA-specific
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Mortality/aging
16 No significant impact
2 Not tested
Data collections
Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:55Adult tissues
50Embryo tissues
| decreased circulating glucose level | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.73x10-5 | ||
| abnormal neural tube closure | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| pale yolk sac | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| pallor | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Adartm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (4/4) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | Section images | 100% (4/4) | 0% (0/394) |
| brain | heterozygote | Section images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 75% (3/4) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Adar mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Adar.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Adartm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Adartm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |