Crlf2 | cytokine receptor-like factor 2
Physiological systems
20 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
8 No significant impact
4 Not tested
Data collections
Gene metrics:20Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged spleen | 2 supporting datasets | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged lymph nodes | 2 supporting datasets | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal lymph node morphology | 2 supporting datasets | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal brain morphology | 1 supporting dataset | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal liver morphology | 2 supporting datasets | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal skin morphology | 2 supporting datasets | Crlf2em1(IMPC)Mbp | homozygote | Late adult | N/A * |
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Human diseases caused by Crlf2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Crlf2.
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| Crlf2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Crlf2tm210874(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |