Hacd3 | 3-hydroxyacyl-CoA dehydratase 3

GeneMGI:1889341Synonyms: Hspc121, B-ind1, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological Cardiovascular system Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal liver morphology	2 supporting datasets	Hacd3^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Early adult	1.65x10^-5
decreased startle reflex	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Early adult	3.37x10^-6
microphthalmia	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
anophthalmia	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Early adult	6.35x10^-5
eye hemorrhage	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Early adult	5.01x10^-5
abnormal vitreous body morphology	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Early adult	5.99x10^-5
abnormal uterus morphology	1 supporting dataset	Hacd3^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hacd3.

Associated images

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Histopathology

There is no histopathology data found for Hacd3.

IMPC related publications

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External links

No external links available for Hacd3.

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*Hacd3^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Hacd3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Hacd3^{tm373820(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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