P3h1 | prolyl 3-hydroxylase 1

GeneMGI:1888921Synonyms: Gros1, 2410024C15Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Integument Adipose tissue Growth/size/body region Limbs/digits/tail Muscle Behavior/neurological Skeleton Cardiovascular system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

3Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal skin morphology	2 supporting datasets	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	4 supporting datasets	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.34x10^-20
thin skin	2 supporting datasets	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral density	1 supporting dataset	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.54x10^-22
decreased bone mineral content	1 supporting dataset	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.47x10^-8
decreased body length	1 supporting dataset	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.44x10^-7
abnormal limb position	1 supporting dataset	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.23x10^-7
decreased locomotor activity	4 supporting datasets	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.58x10^-6
prolonged RR interval	1 supporting dataset	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.25x10^-5
abnormal skeletal muscle morphology	1 supporting dataset	P3h1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for P3h1.

Associated images

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Histopathology

There is no histopathology data found for P3h1.

IMPC related publications

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External links

No external links available for P3h1.

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*P3h1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*P3h1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*P3h1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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