Brd4 | bromodomain containing 4

GeneMGI:1888520Synonyms: MCAP, WI-11513, +1 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial Cardiovascular system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Brd4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal eye posterior chamber depth	2 supporting datasets	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.52x10^-6
abnormal cranium morphology	1 supporting dataset	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.11x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.39x10^-5
decreased prepulse inhibition	3 supporting datasets	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.88x10^-15
decreased total retina thickness	2 supporting datasets	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.31x10^-22
abnormal retina outer nuclear layer morphology	2 supporting datasets	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.79x10^-39
short tibia	1 supporting dataset	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.23x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Brd4^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
increased grip strength	1 supporting dataset	Brd4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.57x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Brd4.

Associated images

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Histopathology

There is no histopathology data found for Brd4.

IMPC related publications

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External links

No external links available for Brd4.

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*Brd4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Brd4^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Brd4^{tm48673(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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