Brd4 | bromodomain containing 4
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial Cardiovascular system
11 No significant impact
5 Not tested
Data collections
Gene metrics:11Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal eye posterior chamber depth | 2 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.52x10-6 | ||
| abnormal cranium morphology | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.11x10-6 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.39x10-5 | ||
| decreased prepulse inhibition | 3 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.88x10-15 | ||
| decreased total retina thickness | 2 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.31x10-22 | ||
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.79x10-39 | ||
| short tibia | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.23x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| increased grip strength | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.57x10-6 |
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Human diseases caused by Brd4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Brd4.
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| Brd4tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Brd4tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Brd4tm48673(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |