Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2

GeneMGI:1861735Synonyms: 4832418D20Rik, 7630402F16Rik

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Vision/eye Cardiovascular system Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating creatinine level	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	heterozygote	Early adult	3.03x10^-9
abnormal retina vasculature morphology	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	heterozygote	Early adult	8x10^-10
preweaning lethality, incomplete penetrance	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
abnormal optic disk morphology	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	heterozygote	Early adult	8.02x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	heterozygote	Early adult	8.23x10^-8
abnormal retina morphology	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	heterozygote	Early adult	8.19x10^-7
abnormal vitreous body morphology	1 supporting dataset	Tmeff2^{em1(IMPC)Hmgu}	heterozygote	Early adult	4.82x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmeff2.

Associated images

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Histopathology

There is no histopathology data found for Tmeff2.

IMPC related publications

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External links

No external links available for Tmeff2.

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*Tmeff2^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Tmeff2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tmeff2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tmeff2^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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