Apbb1ip | amyloid beta precursor protein binding family B member 1 interacting protein

GeneMGI:1861354Synonyms: proline-rich protein 48, Prp48, +1 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal thymus morphology	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.45x10^-6
increased neutrophil cell number	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.12x10^-12
abnormal spleen morphology	2 supporting datasets	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.62x10^-5
increased eosinophil cell number	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.32x10^-5
increased leukocyte cell number	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.41x10^-22
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Apbb1ip^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.32x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Apbb1ip.

Associated images

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Histopathology

There is no histopathology data found for Apbb1ip.

IMPC related publications

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External links

No external links available for Apbb1ip.

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*Apbb1ip^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Apbb1ip^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Apbb1ip^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Apbb1ip^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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