Apbb1ip | amyloid beta precursor protein binding family B member 1 interacting protein
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system
14 No significant impact
3 Not tested
Data collections
Gene metrics:19Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal thymus morphology | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | 1.45x10-6 | ||
| increased neutrophil cell number | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | 2.12x10-12 | ||
| abnormal spleen morphology | 2 supporting datasets | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased spleen weight | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | 2.62x10-5 | ||
| increased eosinophil cell number | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | 2.32x10-5 | ||
| increased leukocyte cell number | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | 8.41x10-22 | ||
| decreased CD8-positive, alpha-beta T cell number | 1 supporting dataset | Apbb1ipem1(IMPC)Ccpcz | homozygote | Early adult | 1.32x10-8 |
| | | | | | | | | | |
Human diseases caused by Apbb1ip mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Apbb1ip.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Apbb1ipem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Apbb1iptm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Apbb1iptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Apbb1iptm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |