Gtpbp2 | GTP binding protein 2
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:41Adult tissues
0Embryo tissues
| enlarged lymph nodes | 1 supporting dataset | Gtpbp2tm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| increased exploration in new environment | 1 supporting dataset | Gtpbp2tm1b(KOMP)Mbp | homozygote | Early adult | 4.42x10-6 | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Gtpbp2tm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Gtpbp2tm1b(KOMP)Mbp | homozygote | Early adult | 5.38x10-9 | ||
| enlarged lymph nodes | 2 supporting datasets | Gtpbp2tm1b(KOMP)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Gtpbp2tm1b(KOMP)Mbp | homozygote | Early adult | 1.44x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 50% (1/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | Section images | 50% (1/2) | 0% (0/335) |
| heart | heterozygote | n/a | 0% (0/2) | 0.36% (2/550) |
Human diseases caused by Gtpbp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Gtpbp2.
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| Gtpbp2tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gtpbp2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gtpbp2tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gtpbp2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |