Cdc20 | cell division cycle 20

GeneMGI:1859866Synonyms: 2310042N09Rik, p55CDC

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Behavior/neurological Mortality/aging Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:49Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to organogenesis	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased heart weight	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.46x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
increased grip strength	2 supporting datasets	Cdc20^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.67x10^-10
increased circulating glucose level	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.51x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.83x10^-10
decreased circulating glucose level	2 supporting datasets	Cdc20^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.43x10^-5
increased fasting circulating glucose level	1 supporting dataset	Cdc20^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.19x10^-30

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdc20.

Associated images

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Histopathology

There is no histopathology data found for Cdc20.

IMPC related publications

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External links

No external links available for Cdc20.

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*Cdc20^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cdc20^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cdc20^{tm214231(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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