Prc1 | protein regulator of cytokinesis 1

GeneMGI:1858961Synonyms: D7Ertd348e

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Adipose tissue Vision/eye Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

cataract1 supporting datasetPrc1tm1b(EUCOMM)HmguheterozygoteEarly adult2.29x10-10 
abnormal retina morphology1 supporting datasetPrc1tm1b(EUCOMM)HmguheterozygoteEarly adult2.77x10-5 
preweaning lethality, complete penetrance1 supporting datasetPrc1tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased total body fat amount2 supporting datasetsPrc1tm1b(EUCOMM)HmguheterozygoteEarly adult3.11x10-5 
persistence of hyaloid vascular system1 supporting datasetPrc1tm1b(EUCOMM)HmguheterozygoteEarly adult3.16x10-5 
abnormal lens morphology1 supporting datasetPrc1tm1b(EUCOMM)HmguheterozygoteEarly adult1.07x10-11 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Prc1em1(IMPC)CcpczExon Deletionmouse
Prc1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Prc1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Prc1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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