Stx7 | syntaxin 7

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Endocrine/exocrine gland Hematopoietic system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased large unstained cell number2 supporting datasetsStx7em1(IMPC)RbrchomozygoteEarly adult3.99x10-5 
small thymus1 supporting datasetStx7em1(IMPC)RbrchomozygoteEarly adultN/A * 
abnormal thymus morphology1 supporting datasetStx7em1(IMPC)RbrchomozygoteEarly adultN/A * 
abnormal circulating phosphate level1 supporting datasetStx7em1(IMPC)RbrchomozygoteLate adult4.1x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Stx7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Stx7em1(IMPC)RbrcIndelmouse
Stx7tm258159(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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