Rab11a | RAB11A, member RAS oncogene family

GeneMGI:1858202

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

1Associated diseases

Expression examined in:48Adult tissues

27Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	1 supporting dataset	Rab11a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Rab11a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.91x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Rab11a^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
improved glucose tolerance	1 supporting dataset	Rab11a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.71x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rab11a.

Associated images

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Histopathology

There is no histopathology data found for Rab11a.

IMPC related publications

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External links

No external links available for Rab11a.

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*Rab11a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rab11a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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