Chek2 | checkpoint kinase 2

GeneMGI:1355321Synonyms: Rad53, CHK2

Physiological systems

18 / 24 physiological systems tested

1 Significantly impacted by the knock-out

Homeostasis/metabolism

17 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:1Significant phenotypes

8Associated diseases

Expression examined in:52Adult tissues

50Embryo tissues

Phenotypes



increased circulating sodium level	1 supporting dataset		Chek2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult		3.92x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chek2.

Associated images

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Histopathology

There is no histopathology data found for Chek2.

IMPC related publications

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External links

No external links available for Chek2.

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*Chek2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Chek2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Chek2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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