Gne | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

GeneMGI:1354951Synonyms: 2310066H07Rik

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Cardiovascular system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased prepulse inhibition	3 supporting datasets	Gne^em1(IMPC)Mbp	heterozygote	Early adult	9.54x10^-6
cataract	1 supporting dataset	Gne^em1(IMPC)Mbp	heterozygote	Early adult	9.23x10^-5
embryonic growth retardation	1 supporting dataset	Gne^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
edema	1 supporting dataset	Gne^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal heart morphology	1 supporting dataset	Gne^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Gne^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Gne^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Gne^em1(IMPC)Mbp	heterozygote	Early adult	7.3x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Gne^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Gne^em1(IMPC)Mbp	heterozygote	Early adult	1x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gne.

Associated images

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Histopathology

There is no histopathology data found for Gne.

IMPC related publications

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External links

No external links available for Gne.

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*Gne^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Gne^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gne^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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