Acsl4 | acyl-CoA synthetase long-chain family member 4
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal tibia morphology | 1 supporting dataset | Acsl4tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 8.36x10-5 | ||
| decreased circulating chloride level | 1 supporting dataset | Acsl4tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.07x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Acsl4tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.29x10-5 | ||
| decreased body weight | 3 supporting datasets | Acsl4tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 7.44x10-6 | ||
| thrombocytopenia | 1 supporting dataset | Acsl4tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.29x10-5 | ||
| decreased body length | 1 supporting dataset | Acsl4tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.1x10-11 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Acsl4tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Acsl4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Acsl4.
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| Acsl4tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |