Thop1 | thimet oligopeptidase 1

GeneMGI:1354165Synonyms: EP24.15

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Vision/eye Hematopoietic system Cardiovascular system Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Late adult	4.11x10^-7
abnormal testis morphology	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal retina vasculature morphology	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Late adult	5.34x10^-7
abnormal kidney morphology	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Early adult	2.35x10^-6
decreased leukocyte cell number	1 supporting dataset	Thop1^em1(IMPC)Mbp	homozygote	Late adult	5.64x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Thop1.

Associated images

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Histopathology

There is no histopathology data found for Thop1.

IMPC related publications

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External links

No external links available for Thop1.

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*Thop1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Thop1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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