Sirt6 | sirtuin 6

GeneMGI:1354161Synonyms: 2810449N18Rik

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin concentration	1 supporting dataset	Sirt6^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.94x10^-5
increased circulating cholesterol level	1 supporting dataset	Sirt6^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.4x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sirt6.

Associated images

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Histopathology

There is no histopathology data found for Sirt6.

IMPC related publications

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External links

No external links available for Sirt6.

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*Sirt6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Sirt6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sirt6^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Sirt6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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