Zfp503 | zinc finger protein 503
Physiological systems
22 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Embryo Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Craniofacial Renal/urinary system
9 No significant impact
2 Not tested
Data collections
Gene metrics:20Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal optic disk morphology | 1 supporting dataset | Zfp503em1(IMPC)Mbp | heterozygote | Early adult | 1.96x10-13 | ||
| abnormal placenta vasculature | 1 supporting dataset | Zfp503em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| enlarged lymph nodes | 2 supporting datasets | Zfp503em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Zfp503em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 2 supporting datasets | Zfp503em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Zfp503em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| increased exploration in new environment | 1 supporting dataset | Zfp503em1(IMPC)Mbp | heterozygote | Early adult | 1.08x10-5 | ||
| edema | 1 supporting dataset | Zfp503em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| microcephaly | 1 supporting dataset | Zfp503em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Zfp503em1(IMPC)Mbp | homozygote | E15.5 | N/A * |
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Human diseases caused by Zfp503 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Zfp503.
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| Zfp503em1(IMPC)Mbp | Whole-gene deletion | | mouse |
| Zfp503tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zfp503tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zfp503tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Zfp503tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |