Angptl3 | angiopoietin-like 3

GeneMGI:1353627Synonyms: hypl

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Phy. System:



decreased circulating cholesterol level	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.05x10^-14
enlarged lymph nodes	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
enlarged uterus	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.05x10^-11
increased fasting circulating glucose level	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	3.41x10^-6
hydrometra	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating triglyceride level	1 supporting dataset	Angptl3^{tm2b(KOMP)Wtsi}	homozygote	Early adult	5.43x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Angptl3.

Associated images

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Histopathology

There is no histopathology data found for Angptl3.

IMPC related publications

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External links

No external links available for Angptl3.

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*Angptl3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Angptl3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Angptl3^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Angptl3^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Angptl3^{tm36403(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Angptl3^{tm36403(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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