Lcmt1 | leucine carboxyl methyltransferase 1
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
12 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased spleen weight | 1 supporting dataset | Lcmt1em1(IMPC)Rbrc | heterozygote | Late adult | 9.66x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Lcmt1em1(IMPC)Rbrc | heterozygote | Late adult | N/A * | ||
| abnormal circulating phosphate level | 1 supporting dataset | Lcmt1em1(IMPC)Rbrc | heterozygote | Late adult | 1.75x10-5 | ||
| increased large unstained cell number | 1 supporting dataset | Lcmt1em1(IMPC)Rbrc | heterozygote | Late adult | 1.72x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Lcmt1em1(IMPC)Rbrc | homozygote | Early adult | N/A * | ||
| abnormal locomotor activation | 1 supporting dataset | Lcmt1em1(IMPC)Rbrc | heterozygote | Late adult | 8.53x10-5 |
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Human diseases caused by Lcmt1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lcmt1.
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| Lcmt1em1(IMPC)Rbrc | Exon Deletion | | mouse |
| Lcmt1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lcmt1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |