Pttg1 | pituitary tumor-transforming gene 1

GeneMGI:1353578Synonyms: PTTG, securin

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:41Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small testis	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased grip strength	2 supporting datasets	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.23x10^-7
small spleen	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating creatinine level	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.41x10^-6
abnormal seminal vesicle morphology	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.72x10^-6
abnormal cholesterol homeostasis	1 supporting dataset	Pttg1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.98x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pttg1.

Associated images

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Histopathology

There is no histopathology data found for Pttg1.

IMPC related publications

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External links

No external links available for Pttg1.

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*Pttg1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Pttg1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Pttg1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pttg1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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