Arhgef1 | Rho guanine nucleotide exchange factor 1

GeneMGI:1353510Synonyms: Lsc, Lbcl2

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Immune system Hematopoietic system Mortality/aging

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased CD4-positive, alpha-beta memory T cell number	2 supporting datasets	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased gamma-delta T cell number	1 supporting dataset	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	3 supporting datasets	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased immature NK cell number	2 supporting datasets	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased hematocrit	1 supporting dataset	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.75x10^-5
increased erythrocyte cell number	1 supporting dataset	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.06x10^-5
increased monocyte cell number	1 supporting dataset	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive NK cell number	4 supporting datasets	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased CD8-positive, alpha-beta T cell number	2 supporting datasets	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mature NK cell number	1 supporting dataset	Arhgef1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef1.

Associated images

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Histopathology

There is no histopathology data found for Arhgef1.

IMPC related publications

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External links

No external links available for Arhgef1.

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*Arhgef1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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