Slc25a4 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

GeneMGI:1353495Synonyms: adenine nucleotide translocase-1, Ant1

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Skeleton Cardiovascular system

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased heart weight	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.37x10^-14
improved glucose tolerance	2 supporting datasets	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.98x10^-11
increased circulating insulin level	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.14x10^-6
increased blood urea nitrogen level	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.31x10^-5
decreased circulating chloride level	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.1x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.56x10^-5
increased circulating calcium level	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.38x10^-25
fusion of vertebral arches	1 supporting dataset	Slc25a4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.17x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc25a4.

Associated images

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Histopathology

There is no histopathology data found for Slc25a4.

IMPC related publications

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External links

No external links available for Slc25a4.

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*Slc25a4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Slc25a4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Slc25a4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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