Mmp20 | matrix metallopeptidase 20 (enamelysin)

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Hematopoietic system Skeleton Craniofacial

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal tooth morphology	3 supporting datasets	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	2 supporting datasets	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal tooth color	2 supporting datasets	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small seminal vesicle	1 supporting dataset	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased body weight	2 supporting datasets	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.82x10^-7
abnormal seminal vesicle morphology	1 supporting dataset	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	1 supporting dataset	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.44x10^-6
abnormal spleen morphology	1 supporting dataset	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	2 supporting datasets	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased prepulse inhibition	1 supporting dataset	Mmp20^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.82x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmp20.

Associated images

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Histopathology

There is no histopathology data found for Mmp20.

IMPC related publications

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External links

No external links available for Mmp20.

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*Mmp20^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Mmp20^{tm208731(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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