Hdgfl3 | HDGF like 3
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Integument Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton Renal/urinary system
11 No significant impact
6 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| hyperactivity | 5 supporting datasets | Hdgfl3em1(IMPC)Tcp | homozygote | Early adult | 1.8x10-7 | ||
| decreased body length | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Late adult | 4.44x10-5 | ||
| increased exploration in new environment | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Middle aged adult | 9.32x10-5 | ||
| enlarged urinary bladder | 2 supporting datasets | Hdgfl3em1(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Late adult | 6.75x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Late adult | 1.01x10-5 | ||
| decreased grip strength | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Early adult | 3.56x10-5 | ||
| decreased grip strength | 2 supporting datasets | Hdgfl3em1(IMPC)Tcp | homozygote | Late adult | 1.46x10-7 | ||
| increased exploration in new environment | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Late adult | 7.71x10-9 | ||
| abnormal eye morphology | 1 supporting dataset | Hdgfl3em1(IMPC)Tcp | homozygote | Early adult | N/A * |
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Human diseases caused by Hdgfl3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Hdgfl3.
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| Hdgfl3em1(IMPC)Tcp | Exon Deletion | | mouse |
| Hdgfl3tm114221(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |