Iqgap1 | IQ motif containing GTPase activating protein 1
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton
12 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| short tibia | 1 supporting dataset | Iqgap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.54x10-16 | ||
| increased grip strength | 2 supporting datasets | Iqgap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.69x10-6 | ||
| decreased bone mineral density | 1 supporting dataset | Iqgap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.79x10-6 | ||
| increased lymphocyte cell number | 1 supporting dataset | Iqgap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.52x10-14 | ||
| increased leukocyte cell number | 1 supporting dataset | Iqgap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.65x10-11 | ||
| decreased exploration in new environment | 1 supporting dataset | Iqgap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.94x10-5 |
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Human diseases caused by Iqgap1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Iqgap1.
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| Iqgap1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Iqgap1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Iqgap1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |