Dtx1 | deltex 1, E3 ubiquitin ligase

GeneMGI:1352744Synonyms: Fxit1

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased exploration in new environment	1 supporting dataset	Dtx1^em1(IMPC)H	homozygote	Early adult	6.8x10^-5
decreased locomotor activity	8 supporting datasets	Dtx1^em1(IMPC)H	homozygote	Late adult	5.92x10^-14
increased circulating cholesterol level	1 supporting dataset	Dtx1^em1(IMPC)H	homozygote	Early adult	4.1x10^-6
decreased prepulse inhibition	3 supporting datasets	Dtx1^em1(IMPC)H	homozygote	Early adult	8.71x10^-7
decreased exploration in new environment	2 supporting datasets	Dtx1^em1(IMPC)H	homozygote	Late adult	2.64x10^-13
decreased exploration in new environment	1 supporting dataset	Dtx1^em1(IMPC)H	homozygote	Middle aged adult	6.93x10^-8
abnormal locomotor behavior	1 supporting dataset	Dtx1^em1(IMPC)H	homozygote	Late adult	8.03x10^-5
decreased locomotor activity	8 supporting datasets	Dtx1^em1(IMPC)H	homozygote	Early adult	5.23x10^-8
increased circulating glucose level	1 supporting dataset	Dtx1^em1(IMPC)H	homozygote	Early adult	7.73x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dtx1.

Associated images

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Histopathology

There is no histopathology data found for Dtx1.

IMPC related publications

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External links

No external links available for Dtx1.

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*Dtx1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Dtx1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dtx1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Dtx1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Dtx1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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