Igfbp7 | insulin-like growth factor binding protein 7
Physiological systems
18 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Integument
17 No significant impact
6 Not tested
Data collections
Gene metrics:1Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
| abnormal skin coloration | 1 supporting dataset | Igfbp7tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.79x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Igfbp7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Igfbp7.
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| Igfbp7tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Igfbp7tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Igfbp7tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |