Nr1h3 | nuclear receptor subfamily 1, group H, member 3

GeneMGI:1352462Synonyms: LXR alpha, Unr1

Physiological systems

21 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Renal/urinary system

19 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

0Associated diseases

Expression examined in:146Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal kidney morphology	1 supporting dataset	Nr1h3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Nr1h3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.52x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nr1h3.

Associated images

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Histopathology

There is no histopathology data found for Nr1h3.

IMPC related publications

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External links

No external links available for Nr1h3.

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*Nr1h3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Nr1h3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Nr1h3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Nr1h3^{tm96756(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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