Nr1h3 | nuclear receptor subfamily 1, group H, member 3
Physiological systems
21 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Renal/urinary system
19 No significant impact
3 Not tested
Data collections
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:146Adult tissues
0Embryo tissues
| abnormal kidney morphology | 1 supporting dataset | Nr1h3tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Nr1h3tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.52x10-8 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| adrenal gland | homozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | homozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | homozygote | n/a | n/a | 0% (0/17) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| bone marrow | homozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | homozygote | n/a | 100% (1/1) | 0.86% (5/579) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
Human diseases caused by Nr1h3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nr1h3.
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| Nr1h3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Nr1h3tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Nr1h3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Nr1h3tm96756(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |