Cstf3 | cleavage stimulation factor, 3' pre-RNA, subunit 3

GeneMGI:1351825Synonyms: 4732468G05Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



cataract	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.37x10^-8
abnormal retina blood vessel morphology	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.86x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.69x10^-8
abnormal retina vasculature morphology	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.99x10^-7
abnormal retina morphology	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.31x10^-6
abnormal lens morphology	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.19x10^-9
preweaning lethality, complete penetrance	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Cstf3^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	7.43x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cstf3.

Associated images

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Histopathology

There is no histopathology data found for Cstf3.

IMPC related publications

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External links

No external links available for Cstf3.

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*Cstf3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cstf3^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cstf3^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cstf3^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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