Pdhx | pyruvate dehydrogenase complex, component X

GeneMGI:1351627Synonyms: Pdx1

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Vision/eye Cardiovascular system Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



persistence of hyaloid vascular system	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.52x10^-15
abnormal retina blood vessel morphology	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.89x10^-8
cataract	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.4x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.46x10^-9
preweaning lethality, complete penetrance	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.17x10^-5
abnormal retina morphology	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.09x10^-8
decreased total retina thickness	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.1x10^-6
abnormal lens morphology	1 supporting dataset	Pdhx^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.89x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdhx.

Associated images

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Histopathology

There is no histopathology data found for Pdhx.

IMPC related publications

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External links

No external links available for Pdhx.

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*Pdhx^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pdhx^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pdhx^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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