Gyg1 | glycogenin 1
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Behavior/neurological Skeleton Cardiovascular system Mortality/aging
17 No significant impact
3 Not tested
Gene metrics:5Significant phenotypes
4Associated diseases
Expression examined in:49Adult tissues
124Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Gyg1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Gyg1tm1b(KOMP)Wtsi | heterozygote | E18.5 | N/A * | ||
| thick ventricular wall | 1 supporting dataset | Gyg1tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.13x10-5 | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Gyg1tm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| vertebral fusion | 1 supporting dataset | Gyg1tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.25x10-5 | ||
| increased grip strength | 1 supporting dataset | Gyg1tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.47x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Gyg1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gyg1.
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| Gyg1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gyg1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gyg1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |