Exoc6 | exocyst complex component 6
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Integument Behavior/neurological Mortality/aging
18 No significant impact
3 Not tested
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Exoc6tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| pallor | 1 supporting dataset | Exoc6tm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Exoc6tm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal skin appearance | 1 supporting dataset | Exoc6tm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Exoc6tm1b(EUCOMM)Wtsi | heterozygote | E18.5 | N/A * | ||
| hyperactivity | 1 supporting dataset | Exoc6tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.71x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Exoc6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Exoc6.
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| Exoc6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Exoc6tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Exoc6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |