Nufip1 | nuclear FMR1 interacting protein 1

Physiological systems

22 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Behavior/neurological Mortality/aging

20 No significant impact

2 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

embryonic lethality prior to organogenesis1 supporting datasetNufip1em1(IMPC)MbphomozygoteE9.5N/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetNufip1em1(IMPC)MbphomozygoteE15.5N/A * 
increased freezing behavior1 supporting datasetNufip1em1(IMPC)MbpheterozygoteEarly adult5.3x10-9 
enhanced cued conditioning behavior1 supporting datasetNufip1em1(IMPC)MbpheterozygoteEarly adult5.51x10-5 
preweaning lethality, complete penetrance3 supporting datasetsNufip1em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nufip1em1(IMPC)MbpExon Deletionmouse
Nufip1tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Nufip1tm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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