Clnk | cytokine-dependent hematopoietic cell linker

GeneMGI:1351468Synonyms: MIST

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Integument Endocrine/exocrine gland Growth/size/body region Muscle Hematopoietic system Cardiovascular system Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased skeletal muscle mass	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
single kidney	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Clnk^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Clnk.

Associated images

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Histopathology

There is no histopathology data found for Clnk.

IMPC related publications

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External links

No external links available for Clnk.

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*Clnk^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Clnk^{tm185094(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Clnk^{tm379140(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Clnk^{tm409703(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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