Syn3 | synapsin III

GeneMGI:1351334Synonyms: Synapsin IIIa

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



hyperactivity	3 supporting datasets	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.66x10^-11
decreased thigmotaxis	4 supporting datasets	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.74x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.78x10^-5
decreased hematocrit	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.16x10^-9
decreased bone mineral content	2 supporting datasets	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.5x10^-5
increased grip strength	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.58x10^-5
abnormal bone structure	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.48x10^-5
abnormal motor coordination/balance	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.48x10^-5
increased circulating sodium level	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.66x10^-5
decreased erythrocyte cell number	1 supporting dataset	Syn3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.62x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Syn3.

Associated images

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Histopathology

There is no histopathology data found for Syn3.

IMPC related publications

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External links

No external links available for Syn3.

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*Syn3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Syn3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Syn3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Syn3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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