Brd7 | bromodomain containing 7

GeneMGI:1349766Synonyms: CELTIX1, bromodomain protein 75 kDa, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased leukocyte cell number	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	2.87x10^-5
abnormal vocalization	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	9.39x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal coat/ hair morphology	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	8.32x10^-7
increased circulating glucose level	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	6x10^-5
decreased circulating LDL cholesterol level	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	6.98x10^-12
increased blood uric acid level	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	2.41x10^-8
tremors	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	7.33x10^-6
decreased body weight	1 supporting dataset	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	8.58x10^-6
abnormal behavior	4 supporting datasets	Brd7^{tm3a(EUCOMM)Wtsi}	heterozygote	Early adult	1.08x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Brd7.

Associated images

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Histopathology

There is no histopathology data found for Brd7.

IMPC related publications

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External links

No external links available for Brd7.

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*Brd7^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Brd7^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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