Ppp2r5c | protein phosphatase 2, regulatory subunit B', gamma

GeneMGI:1349475Synonyms: 2610043M05Rik, D12Bwg0916e, +3 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased monocyte cell number	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	6.33x10^-5
decreased startle reflex	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	6.06x10^-10
decreased exploration in new environment	2 supporting datasets	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	1.49x10^-7
decreased circulating cholesterol level	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	1.52x10^-5
abnormal spleen morphology	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
irregularly shaped pupil	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	7.36x10^-15
increased circulating alkaline phosphatase level	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	7.39x10^-5
enlarged lymph nodes	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased grip strength	2 supporting datasets	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	1.68x10^-15
decreased lean body mass	1 supporting dataset	Ppp2r5c^em1(IMPC)Mbp	homozygote	Early adult	1.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp2r5c.

Associated images

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Histopathology

There is no histopathology data found for Ppp2r5c.

IMPC related publications

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External links

No external links available for Ppp2r5c.

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*Ppp2r5c^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ppp2r5c^{tm256213(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ppp2r5c^{tm256213(L1L2_gt0_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ppp2r5c^{tm256213(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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