Cln8 | CLN8 transmembrane ER and ERGIC protein
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Renal/urinary system
12 No significant impact
4 Not tested
Data collections
Gene metrics:14Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating phosphate level | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | 4.87x10-5 | ||
| enlarged spleen | 2 supporting datasets | Cln8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | 5.3x10-5 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | 5.99x10-5 | ||
| small liver | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| cataract | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | 6.35x10-5 | ||
| increased circulating serum albumin level | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | 1.47x10-5 | ||
| enlarged kidney | 1 supporting dataset | Cln8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased heart weight | 2 supporting datasets | Cln8em1(IMPC)Mbp | homozygote | Early adult | 2.17x10-5 |
| | | | | | | | | | |
Human diseases caused by Cln8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cln8.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cln8em1(IMPC)Mbp | Intra-exon deletion | | mouse |
| Cln8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cln8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cln8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |