Cln8 | CLN8 transmembrane ER and ERGIC protein

GeneMGI:1349447Synonyms: ceroid-lipofuscinosis, neuronal 8, Tlcd6

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

4 Not tested

Gene metrics:14Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating phosphate level1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adult4.87x10-5 
enlarged spleen2 supporting datasetsCln8em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal retina morphology1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adult5.3x10-5 
abnormal vitreous body morphology1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adult5.99x10-5 
small liver1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal kidney morphology1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adultN/A * 
cataract1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adult6.35x10-5 
increased circulating serum albumin level1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adult1.47x10-5 
enlarged kidney1 supporting datasetCln8em1(IMPC)MbphomozygoteEarly adultN/A * 
increased heart weight2 supporting datasetsCln8em1(IMPC)MbphomozygoteEarly adult2.17x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cln8em1(IMPC)MbpIntra-exon deletionmouse
Cln8tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Cln8tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Cln8tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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