Cln8 | CLN8 transmembrane ER and ERGIC protein

GeneMGI:1349447Synonyms: ceroid-lipofuscinosis, neuronal 8, Tlcd6

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating phosphate level	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	4.87x10^-5
enlarged spleen	2 supporting datasets	Cln8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	5.3x10^-5
abnormal vitreous body morphology	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	5.99x10^-5
small liver	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	6.35x10^-5
increased circulating serum albumin level	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	1.47x10^-5
enlarged kidney	1 supporting dataset	Cln8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Cln8^em1(IMPC)Mbp	homozygote	Early adult	2.17x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Cln8.

Associated images

Loading...

Histopathology

There is no histopathology data found for Cln8.

IMPC related publications

Loading...

External links

No external links available for Cln8.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Cln8^em1(IMPC)Mbp*	Intra-exon deletion	‌	mouse
*Cln8^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cln8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cln8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes