Mecr | mitochondrial trans-2-enoyl-CoA reductase
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Behavior/neurological Mortality/aging
17 No significant impact
5 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:3Significant phenotypes
3Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal response to tactile stimuli | 1 supporting dataset | Mecrtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.64x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mecrtm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal gait | 1 supporting dataset | Mecrtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.48x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Mecr mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mecr.
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| Mecrtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mecrtm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Mecrtm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |