Cops4 | COP9 signalosome subunit 4
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Hematopoietic system Behavior/neurological Mortality/aging
17 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal behavior | 2 supporting datasets | Cops4tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 2.82x10-6 | ||
| decreased locomotor activity | 2 supporting datasets | Cops4tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 4.48x10-7 | ||
| increased startle reflex | 5 supporting datasets | Cops4tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 5.83x10-13 | ||
| increased hemoglobin content | 1 supporting dataset | Cops4tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 6.28x10-7 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Cops4tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 1.86x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Cops4tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Cops4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cops4.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cops4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cops4tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cops4tm44610(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |